Genetic Testing Saves Lives
Live A Proactive Life. Know The Risks
Genetic Testing Leads To Life-Saving Interventions
What would you do if you knew you had a genetic predisposition to cancer? Would you live differently? Genetic testing can help you take a proactive approach to your health. Make informed decisions about your health. It’s Better To Know.
These days, medicine has evolved to become more precise. Genetic tests are incredibly valuable for people who come from families where certain cancers or diseases are prevalent. Some of us have a higher than average risk of developing these illnesses- especially cancers associated with hereditary cancer syndromes (HCS).
What Genetic Testing Looks For
Better To Know uses an Inherited Cancer Genetics (ICGx) test which uses next-generation sequencing to look for pathogenic, or disease-causing, genetic variants in 38 genes. Our targeted sequencing approach provides depth and breadth, facilitating actionable insight towards personalized care. We offer multiple panel selections, including a comprehensive panel that covers 20 different types of cancer. Our panels are categorized based on cancer type(s).
Types Of Cancer Our Genetic Testing Examines
Our ICGx Panels offer 9 cancer-type specific panels as well as a comprehensive panel. Here are the specific gene variants we look for under each cancer:
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Genes Tested: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11A, MUTYH, NBN, NF1, PALB2, PTEN, RAD50, RAD51C, STK11, TP53
HCS: Hereditary Breast and Ovarian Cancer (HBOC), Hereditary Diffuse Gastric Cancer (HDGC), Li-Fraumeni Syndrome (LFS), neurofibromatosis type 1, Peutz-Jeghers syndrome (
Female Reproductive Tract Cancers
Genes Tested: BRCA1, BRCA2, BRIP1, EPCAM, MLH1, MSH2, MSH6, PMS2, PTEN, RAD51C, RAD51D, STK11
HCS: Hereditary Breast and Ovarian Cancer (HBOC), Lynch Syndrome, Hereditary Diffuse Gastric Cancer (HDGC), Peutz-Jeghers syndrome (
Genes Tested: APC, BMPR1A, CDH1, EPCAM, FANCC, MLH1, MSH2, MSH6, PMS2, SMAD4, STK11
HCS: Classic and attenuated familial adenomatous polyposis syndromes (FAP and AFAP), Hereditary Diffuse Gastric Cancer (HDGC), Juvenile Polyposis Syndrome (JPS), Lynch syndrome*, Peutz-Jeghers syndrome (PJS)
Genes Tested: STK11, TP53
HCS: Li-Fraumeni Syndrome (LFS), Peutz-Jeghers syndrome (PJS)
Genes Tested: CDK4, CDKN2A, PTEN
HCS: Familial malignant melanoma, PTEN hamartoma tumor syndrome (PHTS) spectrum
Genes Tested: APC, BRCA1, BRCA2, CDKN2A, EPCAM, MEN1, MLH1, MSH2, MSH6, PALLD, PMS2, STK11, TP53, VHL
HCS: Classic and attenuated familial adenomatous polyposis syndromes (FAP and AFAP), familial malignant melanoma, Hereditary Breast and Ovarian Cancer (HBOC), Li-Fraumeni Syndrome (LFS), Lynch syndrome*, Multiple Endocrine Neoplasia type I (MEN1), Peutz-Jeghers syndrome (
Genes Tested: BRCA1, BRCA2, CHEK2, ELAC2, NBN, TP53
HCS: Hereditary Breast and Ovarian Cancer (HBOC), hereditary prostate cancer, Li-Fraumeni Syndrome (LFS)
Genes Tested: APC, BMPR1A, EPCAM, MET, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, TP53, VHL.
HCS: Classic and attenuated familial adenomatous polyposis syndromes (FAP and AFAP), Constitutional Mismatch Repair Deficiency Syndrome (CMMRD), Hereditary Diffuse Gastric Cancer (HDGC), Hereditary Papillary Renal Cell Carcinoma (HPRC), Juvenile Polyposis Syndrome (JPS), Li-Fraumeni syndrome (LFS), Lynch syndrome*, MUTYH-associated Polyposis syndrome (MAP), PTEN hamartoma tumor syndrome (PHTS), von Hippel-Lindau syndrome
Genes Tested: FANCC, HRAS, PTCH1, RET
HCS: Costello syndrome, Fanconi anemia, Gorlin syndrome (also known as Nevoid Basal Cell Carcinoma Syndrome, or NBCCS), Multiple Endocrine Neoplasia
Covers all genes and all cancer syndromes listed above
Not All Cancers Are Created Equal
It’s a simple fact that most cancers are non-hereditary mutations in the cells that occur over a person’s lifetime. That is why cancers tend to develop in older individuals. These mutations are often caused by environmental factors and errors in DNA replication that occur over the course of normal cell division.
Sometimes cancers may appear to run in a family. When this occurs it’s important to distinguish between shared environmental factors (which cause mutations) and shared genetic causes (or inherited mutations). Both environmental and genetic factors interact to influence cancer predisposition risk.
It’s estimated that approximately 5-10% of cancers are attributed to inherited genetics. In these cases, cancers that occur frequently within a family are due to pathogenic genetic variants that are passed down through multiple generations.
When someone is born with an inherited pathogenic variant, they are more likely to develop cancer at an earlier age than someone without an inherited gene. Depending on the type of variant, he or she may also be more likely to develop multiple types of cancer. Identification of these mutations is essential in determining one’s cancer risk and being proactive.
HCS Is Linked To Multiple Cancer Types & Early Age Onset
Most hereditary cancers involve a diagnosis before the age of 50 in multiple family members. It’s also relatively common to see multiple types of cancer with HCS. For example, people with a strong history of breast and ovarian cancer in their family may be at an elevated risk for developing prostate or pancreatic cancer. Results from our genetic testing can help you better understand which types of cancer you have an increased risk for based upon the genetic variants we see.
Cancer Risks Can Vary
It goes without saying, but your genetic makeup is an incredibly complex puzzle. A single HCS can be caused by pathogenic variants in several different genes. For example, Lynch syndrome is a type of inherited cancer syndrome that is associated with an increased risk of colorectal, endometrial, stomach and ovarian cancers. Knowing that you carry the genes for this syndrome can be invaluable when it comes to preventative care and monitoring options.
Genetic Testing: How To Save A Life
It’s a simple fact that knowing your genetic makeup can help you make important life decisions that can prolong your life. We’re convinced it’s Better To Know. Let us help you discover the truth about yourself and make informed decisions. Order one of our genetic testing kits today.