Our Science

DNA Testing Trusted By The Medical Community.
The Science Behind Our Genetic Testing,

The Science Behind Our Genetic Testing

Modern medicine has advanced in incredible ways- to the point of being able to map out the complex genetic materials that make up who you are. Amazingly, we can do this all with a little swab of saliva. But, your genetic information should never be trusted with just any company.
 
At Better To Know, we use laboratories and procedures that have been providing medical grade genetic testing for physician practices, clinics, other labs and hospitals all across the country- for years now. We’ve only recently decided to make our DNA testing to the public. Shouldn’t you trust the company that provides genetic testing results for the rest of the medical industry?

Stop Wondering!

Trusted Genetic Testing Technology

Our standards are the highest in the medical profession

  • Our labs are CLIA-Certified and COLA accredited recognized by the Joint Commission. This means our labs meet the highest standards applicable to medical laboratories in the United States.
  • Our collection device is simple to use, painless, non-invasive and FDA cleared.
  • We use well-established scientific methods and reliable platforms for genotyping DNA.
  • Our reports are clear, concise and easy to understand.
  • We provide ongoing phone support for our clients.

Your DNA & You

It may be a surprise to you, but more than 99% of human DNA is completely identical from person to person. This means that less than 10% of your genetic material makes you unique. These small differences are referred to as variants.

 While it’s clear that your DNA is passed down from both of your parents, variants in your genetic makeup can be linked to various health conditions. We send a sample collection kit with easy to understand instructions on how to gather your sample.

 Once our lab receives your sample, we will go through the process of genotyping your DNA to look for variants. We provide medical grade genetic testing which follows procedures and protocols that are trusted from top-level clinicians across the country. From there, we generate a highly personalized report.

It’s Better to Understand: Useful Genetics Terms and Concepts

Genetics can seem like a complex topic, and have some terms below to help you better understand. When you order a test from us, we want you to feel informed and confident. Below are some commonly used terms in genetics, along with examples specific for each of our genetic tests when applicable.

Terms are not listed alphabetically. We start with basic concepts and build upwards.

Chromosome– Structures of DNA found in the nucleus of each cell.

Humans have 23 pairs of chromosomes, which contain the genes that compose one’s genotype.

Genes– A single physical unit of inheritance coded for in DNA. Genes are passed on from parent to offspring.

Genes are composed of base pairs of DNA, called nucleotides. There are four nucleotides in DNA, represented by the letters A, T, G, and C.

Genes code for proteins and other important molecules.

Our genes also come in pairs. We get one of each from our biological parents.

Cytochrome P450 (CYP450) genes -CYP is pronounced as “sip.” This family of genes plays a part in the metabolism and breakdown of potentially toxic compounds including drugs and naturally occurring compounds in our bodies.

Allele– Different versions of a gene.

Alleles are also called variants, polymorphisms, or mutations and can influence a variety of different traits.

Mutation -Also referred to as variants, these are permanent alterations in DNA. Not all mutations/variants change the function of a gene or cause disease. Mutations can be large (alter several bases) or small (alter a single base). Mutations are often considered “bad,” but with genetics and genetic testing specifically, this is an incorrect use of the term. Mutations are natural and contribute to the normally occurring variation in a population.

Single Nucleotide Polymorphism– SNP is pronounced as “snip.” A type of variant that changes a single nucleotide (or base) at the DNA level.

 Haplotype– Combinations of genetic variants (such as SNPs) that are likely to be inherited together.

Dominant– Refers to the relationship between two alleles, an allele is dominant if it expresses itself “more strongly” over another allele. For example- Purple flower color is dominant over white flower color. A single purple color allele will mask the white color allele, and a flower will be purple.

Recessive– Understandably, this is the opposite of a dominant allele. An allele is recessive if its expression is “masked” by another dominant allele. A recessive allele will “show itself” when an individual is homozygous for the recessive allele.

Incomplete dominance– Refers to the relationship between alleles. Incomplete dominance occurs when there is a blending of allele products, which results in an outcome that is neither completely dominant or recessive.

 Homozygous– When an individual contains two copies of the same allele.

 Heterozygous– When an individual contains two different alleles. In carrier screening, people heterozygous for one disease-causing allele are called carriers for that disease/condition.

Genotype– An individual’s complete genetic identity. One’s genotype is composed of two sets of chromosomes which are equally inherited from one’s biological mother and father.

Phenotype– The observed manifestation of one’s traits, which is based on the complex interactions between one’s genotype and environment. Phenotypic traits include things such as eye color, personality, and response to drugs.

Polygenic– When many genes influence a single trait.

Pleiotropy– When a single gene influences multiple traits.

What Kind of Technology Is Used To Generate My Genetic Test Results?

 Pharmacogenetics and Carrier Screening

The Pharmacogenic (PGx) tests are a genetic test that is done to help you identify your sensitivity and reactivity to medications. For example, imagine the power of knowing that you don’t respond well to blood thinners? This could be very helpful information. Along with other health information, your doctor can use this report as guidance when selecting the right drug and dosage for you.

Carrier Screening (CSGx) tests are DNA test that helps you identify the likelihood of passing on genetic medical conditions. Based on which alleles are present, we can tell you if you are a carrier for a given genetic disorder. Your doctor or a genetic counselor can use details about your carrier status (and the carrier status of your partner, if tested) to assess your risk of having a child affected by specific recessive conditions.

To get results for both of these DNA tests, we use quantitative real-time polymerase chain reaction (PCR) to detect specific alleles in genes involved in drug metabolism and recessive disorders, respectively. The probes used in quantitative real-time PCR bind to very specific DNA sequences, which allow us to distinguish between alleles down to a single base-pair level.

This is the difference between your typical genetic test for health and a medical grade level genetic testing.

Genetic Testing For Cancer

 We offer genetic screening for cancer to help you identify your risks. Often called an Inherited Cancer Genetics (ICGx) test, we use next-generation sequencing (NGS) to look for genetic variants in 38 genes associated with hereditary cancer syndromes (HCS).

When you combine our report with an in-depth review of your personal and family medical history, you have powerful insight into the next steps to take toward personalized care.

Better To Know provides some of the most technical, trusted at home DNA testing on the market. For years, we’ve been providing genetic testing for the medical community all across the nation. Now, you can get the same results from the comfort of your own home and your mailbox. Order your DNA testing kit today.

Connect with Us

Better To Know is a division of LifeBrite Laboratories

Our Lab

 All our samples are processed in a top-level, national reference laboratory. Our lab is CLIA certified and COLA accredited. This means we are held to the highest standards for all of our policies and procedures. This is why the medical community trusts our results.

Our team has decades of experience and a strong commitment to accuracy as well as excellence. We are dedicated to giving you the results you need to improve your life.

ADDRESS

9 Corporate Blvd NE #150, Atlanta, GA 30329

Phone:  888.711.5669